Are Cannabinoid Products Safe for Individuals with Hypertension — HBP?

Are Cannabinoid Products Safe for Individuals with Hypertension — High Blood Pressure?

    In our history of operation, we have had many customers come to us with inquiries about the safety of our Cannabinoid products in relation to Hypertension (High Blood Pressure). Fortunately, with growing popularity of these types of products, demands for safety and efficacy trials has also increased. If you are curious about the possibility of adding Cannabinoid products into your routine, but remain wary of the effects of these products on your blood pressure level, take a look at this information we’ve gathered.

Studies Exhibit the Safety of Cannabinoid Products for Individuals with Hypertension

    There is no shortage of anecdotal OR clinical evidence about the safety and tolerability of Cannabinoids. In fact, researchers categorize many of these studies by certain conditions, or medication usage. This allows individuals to compile information directly relating to their current situation. Several studies have centered on Hypertension due to the commonality of this condition. 

   Several studies suggest that Cannabidiol remains generally well tolerated and safe in humans at high doses and with chronic use. In human studies, CBD administration did not induce side effects across a wide range of dosages. These included acute and chronic dose regimens; tolerance to CBD did not develop. 

Acute Studies

 In the 1970s, human studies showed that oral CBD intake from 15 to 160mg, inhalation of 0.15mg/kg bw, or intravenous injection from 5 to 30mg were not followed by ill effects. A separate study CBD did not interfere with several psychomotor and psychological functions in humans. Results also showed that CBD does not negatively affect heart rate, blood pressure, or performance in the verbal paired-associate learning test as measured by recall score at doses up to 600mg . Subsequent studies concerning the antipsychotic effects of CBD have not reported any side effects after CBD intake either.  

Chronic Studies

    Chronic oral administration of 10mg CBD daily for 21 days did not induce any changes in neurological, clinical, psychiatric, blood or urine examinations. Likewise, oral CBD administration in healthy participants (3mg/kg bw daily for 30 days) and in epileptic patients (200-300mg daily for 135 days) was well tolerated and no signs of toxicity or serious side effects were detected on neurological and physical examinations, blood and urine analysis, or EKG and EEG, which were performed at weekly intervals

The Bottom Line

    Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy, does not negatively affect physiological parameters (heart rate, blood pressure and body temperature), does not negatively affect gastrointestinal transit and does not negatively alter psychomotor or psychological functions. In conclusion, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. 

Cannabinoid Products Provide Benefits for Individuals with Hypertension

    Hypertension is a common condition wherein the long-term force of the blood against the artery walls is high enough that it may eventually cause health problems, such as heart disease. An individual can have hypertension for years without any symptoms. Even without symptoms, damage to blood vessels and the heart continues allowing medical professionals to detect it. Uncontrolled high blood pressure increases the risk of serious health problems, including heart attack and stroke. Fortunately, a number of preclinical studies have shown beneficial effects of CBD in a range of disorders of the cardiovascular system.

What Existing Studies Tell Us

    One particular study exhibited the ability of a single dose of CBD to reduce resting blood pressure and the blood pressure response to stress, particularly cold stress, and especially in the post-test periods. This may reflect the anxiolytic and analgesic effects of CBD, as well as any potential direct cardiovascular effects. CBD also affected cardiac parameters but without affecting cardiac output. Given the increasing use of CBD as a medicinal product, individuals with Hypertension should consider these hemodynamic changes.

    A 2019 Brazilian study looked at several Cannabidiol dosages and their effect on the stress and anxiety related to public speaking. Public speaking conditions often produce effects such as increased heart rate and increased blood pressure. CBD has known anxiety-reducing properties. This study aimed to investigate whether low (150mg), medium (300mg), and high (600mg) doses would produce positive effects.

  Because anxiety intensity can be measured with vital signs such as heart rate and blood pressure, this study provides an indirect look at the effect of CBD on blood pressure. The data in this study showed that the placebo, low CBD, and high CBD groups all had similar reactions to the anxiety-producing condition of public speaking. However, medium-dose CBD group, by contrast, experienced a notably reduced stress response to stressful environmental factors. Overall, there is likely an optimal dosage for stress, anxiety, and blood pressure control. Even CBD is subject to the law of diminishing returns.  This means increases in the dosage produces better results only to a certain point. 

Could Cannabinoid Products Aid in Managing Hypertension — High Blood Pressure Levels?

    The evidence supporting the positive benefits of Cannabinoids coincides with evidence of it’s safety and tolerability. Both clinical and anecdotal evidence collected in recent years lead to the popularity of this compound. Check out our shop for Cannabinoid Products aimed at providing relief and aiding in the management of chronic conditions.