Cannabinoids Effects on Hashimoto’s Thyroiditis – Hypothyroidism
According to the American Thyroid Association, more than 12 percent of the U.S. population will develop a thyroid condition during their lifetime. In fact, an estimated 20 million Americans have some form of thyroid disease. 2 These conditions can be incredibly dangerous and difficult to detect. Consequently, up to 60 percent of those with thyroid disease are unaware of their condition. This gland, located at the base of the neck, functions as part of the Endocrine System. The Thyroid Gland produces two thyroid hormones: thyroxine (T4) and triiodothyronine (T3). Thyroid hormones control how the body uses energy, so they affect nearly every organ in your body, even your heart. 1
Hashimoto’s Disease is a fairly common condition in which the immune system attacks the Thyroid Gland causing it to become inflamed. Inflammation from Hashimoto’s disease, also known as chronic lymphocytic thyroiditis, leads to an underactive thyroid gland. An underactive Thyroid can wreak havoc on the system causing a plethora of symptoms. Hashimoto’s disease is the most common cause of hypothyroidism in the United States. It primarily affects middle-aged women but also can occur in men and women of any age and in children. 3
Symptoms of Hashimoto’s Disease and Hypothyroidism
Often the signs and symptoms of Hashimoto’s disease remain undetected at first. Those who do notice changes, may notice a swelling at the front of the throat (goiter). Typically, Hashimoto’s disease progresses slowly over years and causes chronic thyroid damage. This damage leads to a drop in thyroid hormone levels in the blood. The signs and symptoms associated with this condition are mainly those of an underactive thyroid gland (hypothyroidism).
Symptoms of Hypothyroidism – Hashimoto’s include fatigue, sore muscles and muscular stiffness, joint pain and stiffness, depression and anxiety, memory lapses and much more.
Cannabinoids Aid in the Management of Symptoms
Cannabinoids Offer Anti-inflammatory Benefits
Cannabidiol (CBD) functions as a potent anti-inflammatory agent. Effective in suppressing IFN-γ and TNF-α (pro-inflammatory cytokines) production and progression of autoimmune conditions by inhibition of T cell proliferation, Cannabidiol has spiked interest in the medical research community. These findings provide compelling evidence for the use of CBD in the treatment of inflammation and neuroprotection both in terms of its efficacy and safety. The anti inflammatory action of CBD on cisplatin-induced inflammation, and tissue injury in the kidney was studied using an established mouse model of cisplatin-induced nephropathy. CBD treatment reduced mRNA expression of those pro-inflammatory cytokines. 6 Interestingly, several markers of nephrotoxicity also lowered. This information indicates that Cannabidiol acts as an effective anti inflammatory.
Cannabinoids Exert Changes in Sleep-Wake Cycles
Administration of CBD displayed differential effects on sleep based on dose. In fact, low-dose CBD has a stimulating effect, while high-dose CBD has a sedating effect. In a study among individuals with insomnia, results suggested that administration of high amounts of CBD increased total sleep time and decreased the frequency of arousals during the night, while low-dose CBD caused an increase wakefulness in several studies. Experimental evidence indicates the potential role of CBD in managing excessive sleepiness. In fact, recent work on sleep and early morning behavior demonstrates CBD’s impact on wakefulness. In one study, CBD administered in a 1:1 ratio counteracted the sedative effect of THC. These effects become further influenced by the dosage, ratio of cannabinoids, timing of administration, and route of administration. 7
Mood Altering Benefits of Cannabinoids
Evidence gathered by the medical and scientific community supports the theory that Cannabinoids can be effective at mood altering, in a positive manner. In fact, one research team conducted an in vivo study to assess the prohedonic (offering positive sensations) effects of CBD. CBD showed a prohedonic effect on the test rats, indicating an improvement in the characteristically low motivation of the rats to explore. These findings extend the limited knowledge on the antidepressant effect of CBD, now shown for the first time in a genetic animal model of depression. These results suggest that CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia (negative emotions, unpleasantness). 8
Much research associates Cannabidiol with anxiety relieving benefits. The anxiolytic effects of CBD in humans were first demonstrated in the context of reversing the anxiogenic effects of THC. Cannabidol reduced THC-induced anxiety when administered simultaneously with this agent. CBD potently reduces experimentally induced anxiety or fear. CBD reduced anxiety associated with a simulated public speaking test in healthy subjects, and in subjects with SAD, showing a comparable efficacy to ipsapirone (a 5-HT1AR agonist) or diazepam. This compound also reduced the presumed anticipatory anxiety associated with undergoing a single-photon emission computed tomography (SPECT) imaging procedure, in both healthy and Social Anxiety Disorder subjects.This evidence suggests that Cannabinoids offer positive mood altering mechanisms. 9
Cannabinoids Exhibit Neuroprotective Activities
Additionally, the neuroprotective actions of cannabidiol and other cannabinoids were examined. In these models rat cortical neuron cultures were exposed to toxic levels of the excitatory neurotransmitter glutamate. Glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of Cannabis, and the psychotropic cannabinoid (−)Δ9-tetrahydrocannabinol (THC). Previous studies have shown that glutamate toxicity may be prevented by antioxidants. Cannabidiol, THC and several other cannabinoids were all demonstrated to be antioxidants by cyclic voltametry. These Cannabinoids were also shown to prevent hydroperoxide-induced oxidative damage as well as or better than other antioxidants in a chemical (Fenton reaction) system in neuronal cultures. Cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or α-tocopherol, indicating it to be a potent antioxidant. This evidence also suggests that Cannabidiol may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia. 11
Cannabinoids Target the Root of the Issue; Auto-Immune Dysfunction
CBD exhibited the ability to modulate the function of the immune system. This Cannabinoid exhibits several anti-inflammatory activities and regulates cell cycle and immune cells functions. CBD is able to suppress the production of a wide range of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin-1 beta (IL-1β), chemokines, growth factors, as well as inhibition of immune cell proliferation, activation, maturation, migration and antigen presentation. 5 During neuroinflammation, activated microglial cells migrate towards the site of injury where they release pro-inflammatory cytokines and cytotoxic agents. 4
Are Cannabinoid Products and Option for Your Relief?
If these symptoms sound familiar to you, Cannabinoid products may be an alternative option for relief. Our shops carry Topical Salves and Oils intended for local relief of joint and muscle aches and pains, while Tincture Alternatives and Capsules remain ideal for Immune Health and Systemic Relief. Check out our shop to find the right products for your needs.