Cannabinoid Products can Aid Ankylosing Spondylitis Sufferers
Ankylosing Spondylitis is an inflammatory disease that can cause some of the vertebrae in your spine to fuse. Many health professionals consider this condition a type of Arthritis as the inflammation primarily affects the spine and other joints. In advanced cases, this inflammation leads to ankylosis causing sections of the spine to fuse in a fixed, immobile position.
Ankylosing Spondylitis can also cause inflammation, pain, and stiffness in other areas of the body such as the shoulders, hips, ribs, heels, and small joints of the hands and feet. Sometimes the eyes can become involved (known as iritis or uveitis), as well as the lungs and heart. Ankylosing spondylitis affects the sacroiliac (SI) joints during the progression of the disease. The SI joints are located at the base of the spine, where the spine joins the pelvis. Ankylosing spondylitis affects men more often than women. Signs and symptoms typically begin in early adulthood. There is no cure for ankylosing spondylitis, but treatments can lessen symptoms and possibly slow the progression of disease.
Many Cannabinoids offer Anti-inflammatory Benefits
Countless studies have exhibited the anti-inflammatory benefits of several Cannabinoids derived from the Cannabis plant. Healthy Hempies utilizes several of these Cannabinoids in products aimed at relieving inflammatory diseases, like Ankylosing Spondylitis.
Anti-Inflammatory Profile of Cannabidiol
Cannabidiol remains arguably one of the most well-known Cannabinoids derived from the Cannabis plant. CBD is a compound with potentially broad therapeutic applications, which possesses a potent anti-inflammatory effect, several hundred times that of aspirin.
One particular article from the Journal of Controlled Release outlines results that prove that CBD delivered systemically to the inflamed organ enabled therapeutic anti-inflammatory levels at the site. This study suggests that trans-dermal CBD may be valuable in the treatment of chronic inflammatory diseases.
Other findings suggest that the therapeutic action of CBD in arthritis includes the suppression of TNF-a, a pro-inflammatory cytokine known to be a major mediator of this disease. Cytokines are signaling proteins synthesized and secreted by immune cells upon stimulation. They are the modulating factors that balance initiation and resolution of inflammation. One of the possible mechanisms of immune control by cannabinoids during inflammation lies the dysregulation of cytokine production by immune cells and disruption of the well-regulated immune response.
Additionally, studies demonstrated that CBD enhances adenosine signaling through inhibition of uptake and provides further non cannabinoid-receptor mechanisms by which CBD decreases inflammation.
Finally, plant cannabinoids are monophenols. Phenols are well-known antioxidants. Likewise Cannabinoids are powerful antioxidants. This data suggests that CBD may be a useful therapeutic agent for the treatment of oxidative disorders which cause inflammation.
Anti-inflammatory Benefits of Cannabichromene
Several studies have exhibited the efficacy of Cannabichromene (CBC) to induce hypothermia, reduce inflammation, and as antimicrobial agents. Cannabichromene successfully reduces inflammation and relieves pain in diseases such as arthritis, as well as to reduce and control edema. Several Patents, such as US6949582B1, outline these benefits. This particular patent reviews a method of relieving a human patient of pain, discomfort and tissue inflammation associated with arthritis, bursitis, fibromyalgia, carpal tunnel syndrome, or gout, by topically applying to the skin of the patient a liquid cannabinoid composition.
Anti-inflammatory Benefits of Cannabigerol
Additionally, several patents outline the use of Cannabigerol (CBG) for treatment of diseases and conditions benefiting from concurrent agonism of the CB1 and the CB2 cannabinoid receptors. Such diseases or conditions to be treated are taken from the group: pain, neurodegenerative disease, age related inflammatory or autoimmune disease, movement disorders, rheumatoid arthritis, and osteoporosis. In addition, the topical use of cannabinoid extracts as an analgesic has been described in US6949582. The cannabinoid extract of the patent includes all of the naturally occurring cannabinoids, terpenes and flavinoids found in cannabis plant extracts. Consequently, this includes cannabinoid, Cannabigerol.
Cannabinoids Could Aid Individuals Suffering Ankylosing Spondylitis