Psoriasis is a condition that affects the skin causing skin cells to multiply at an increased rate. This causes the cells to build up on the surface forming scaly red and white patches. This buildup can cause inflammation and itching. According to the National Psoriasis Foundation, Scientists believe that at least 10 percent of people inherit one or more of the genes that could eventually lead to psoriasis and 2 to 3 percent of the population develops the disease. Current studies reflect that 8 million Americans live with Psoriasis and the symptoms thereof day after day.
Scientists have now identified about 25 genetic variants that make a person more likely to develop psoriatic disease. At the University of Michigan, Dr. J.T. Elder and his team of researchers identified several areas on the human genome where more than one gene affects psoriasis and psoriatic arthritis activity. Certain environmental factors can trigger psoriatic activity in the body. Possible triggers to this condition include injury to skin, infection, medications, and stress.
How Cannabinoid Products Provide Relief
Psoriasis is a chronic condition that causes painful symptoms that will come and go several times. The main goal of any treatment would be to slow the overproduction of cells. There is no proven cure to this condition but it is possible for an individual to manage the symptoms that accompany it. Symptoms of Psoriasis exert individualistic results, however common symptoms include red patches of skin, white or silvery thick scales forming on skin, dry cracked skin that bleeds often, topical itching burning or inflammation, and sore inflamed joints.
Cannabinoid Products Reduce Inflammation
The Endocannabinoid System exists widespread in tissues and cells and plays a role in homeostasis (the balance each body needs to be well) by activating after any disruption of that balance and regulating the levels and action of other chemical signals. It is becoming increasingly clear that cannabinoid receptors (and the molecules that bond to and stimulate them) play a crucial role in the regulation of the immune system.
Exogenous cannabinoids, such as those from Hemp or Cannabis, suppress T-cell-mediated immune responses. This is achieved by primarily inducing apoptosis and suppressing inflammatory cytokines and chemokines (inflammatory signaling molecules). Cannabinoids offer promising results in studies and models of inflammatory responses. Cannabinoids such as Cannabidiol and Cannabinol have shown antioxidant and anti-inflammatory affect on immune cells amongst other properties. In fact, several pharmaceutical companies received medical patents for the use of Cannabinoids as therapeutic agents for chronic inflammatory and pain conditions.
Slowing Cell Proliferation with Cannabinoid Use
Both in vivo and in vitro studies have been completed in an attempt to provide sufficient evidence that Cannabinoids could inhibit proliferation of certain cells. Because of their implication in proliferation (rapid reproduction of cells), apoptosis (death of cells), and angiogenesis (development of blood vessels), researchers believe that cannabinoids regulate certain cell growth. In fact, they investigated the plant cannabinoids Δ-9 tetrahydrocannabinol, cannabidiol, cannabinol and cannabigerol. Scientists observed their ability to inhibit the proliferation of a hyper-proliferating human keratinocyte cell line and the involvement of cannabinoid receptors. Results exhibited that cannabinoids inhibit keratinocyte proliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis.
Cannabinoid Use Promotes Immune Health
Endocannabinoids are believed to control immune functions and play a role in immune homeostasis. Immune cells express both CB1 and CB2 receptors, secrete endocannabinoids and have functional cannabinoid transport/breakdown mechanisms. Human peripheral blood immune cells exhibit different degrees of Cannabinoid receptor expression. Certain findings support the role of endocannabinoids as local modulators of immune and inflammatory reactions. Growing research suggests that the Endocannabinoid system directly affects immune functions. If there is dysfunction of immune cells there may be a lack or disruption in Endocannabinoid production or function.
Because Cannabidiol elevates the 2-AG endocannabinoid levels, it may be able to help with autoimmune diseases. The 2-AG endocannabinoid travels from the receiving cell to the sending cell with a message to stop sending out so many attack cells. While CBD suppresses immune functions, it doesn’t stop all immune cells from being sent out. This may be the reason that people can still heal from injuries while reducing inflammation.
Reducing Stress and Anxiety with Cannabinoid Products
CBD has a broad pharmacological profile, including interactions with several receptors known to regulate fear and anxiety-related behaviors. Systemically administered CBD reduced increases in heart rate and blood pressure and delayed anxiogenic effects of stress. Overall, existing preclinical evidence strongly supports the potential of CBD as a treatment for anxiety disorders. CBD exhibits a broad range of actions, relevant to multiple functions, including anxiolytic, panicolytic, and anti-compulsive actions and prevention of the long-term anxiogenic effects of stress.
Are Cannabinoid Products an Option for Your Psoriatic Symptoms?
Fortunately, Cannabinoid Products are available in many forms and each method will offer its own benefits. Psoriasis sufferers may find that Topical Salves work well for quick-acting relief, or that Tincture Alternatives will provide long lasting coverage for their symptoms. Check out our shop for product specifications!